Mindfulness Engaged Neurostimulation for Depression (MEND II)
ClinicalTrials.gov ID NCT07512284 · Mindfulness Engaged Neurostimulation for Depression
Checking if you qualify through this page is for people in California.
At a glance
- Status
- Recruiting
- Condition
- Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder, Depressive Symptoms
- Phase
- Phase 2
- Ages
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Not accepted
- What is being studied
- Medi-TBS (combination product)
- Sponsor
- University of California, San Diego
- Target enrollment
- 120 participants
- Study sites
- 1 open in California
- Start date
- 2026-05-01
- Primary completion
- 2029-04-30
Common questions
Is NCT07512284 still recruiting?
ClinicalTrials.gov lists this trial as recruiting (checked 23 October 2026). It has 1 open or upcoming sites.
Who can take part in NCT07512284?
The record lists people aged 18 to 65 years with depression, treatment resistant depression, major depressive disorder, depressive disorder, depressive symptoms. The study team decides who is eligible, and the full criteria are on this page and in the official record.
Where is NCT07512284 running?
1 site in California, according to ClinicalTrials.gov.
What is being studied in NCT07512284?
It is a Phase 2 trial. The record lists this intervention: Medi-TBS. The sponsor is University of California, San Diego.
How many people will NCT07512284 enroll?
The record gives a target of 120 participants.
How do I sign up for NCT07512284?
Use "Check if you may qualify" on this page to answer a few screening questions, or contact the study team listed on ClinicalTrials.gov.
About this trial
From the ClinicalTrials.gov record.
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.
Where it's running
| Site | City | State | Status |
|---|---|---|---|
| UC San Diego Health Psychiatry | San Diego | California | Recruiting |
Full eligibility criteria (from the record)
Inclusion Criteria: * Diagnosis of major depressive episode (MDE, in accordance with the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5), in the context of unipolar major depressive disorder. * At least one failed antidepressant medication trial at level 3 in the Antidepressant -Treatment History Form: Short Form (ATHF-SF) classification. * Montgomery-Åsberg Depression Rating Scale (MADRS) Score \>19 (moderate - severe depression). * No increase or initiation of new antidepressant therapy in the four weeks prior to screening. * Demonstrated capacity to give informed consent. Exclusion Criteria: * Inability to provide informed consent. * Medically unstable patients. * Concomitant neurological disorder or a history of a seizure disorder. * Exhibiting current suicidal behavior rating on the Columbia Suicide Severity Rating Scale (C-SSRS) * Patients who are pregnant or breastfeeding. * Any psychotic disorder or current active psychotic symptoms. * Patients who have intracranial implants, other medical device or condition deemed unsafe for TMS. * Contraindication to MRI scanning.
Other recruiting trials: Depression clinical trials · Depression clinical trials in California · Depression (major depressive disorder) clinical trials
This listing shows only what the public ClinicalTrials.gov record NCT07512284 says, last updated there on 2026-05-06. It was checked against the registry on 23 October 2026. Taking part is voluntary, and the study team decides who is eligible. For the most current details, see the official record.
