Depression (major depressive disorder) clinical trials
Medical name: Major depressive disorder · Mental health
By location or age: Texas
691 trials are recruiting, according to ClinicalTrials.gov.
Showing 100 of 691, newest first. Checked against the registry on 5 October 2026. Listing a trial here is not a recommendation; taking part is voluntary and each study team decides who is eligible.
Study of ALTO-300 in MDD
Ages 18 Years to 70 Years · 38 sites · Alto Neuroscience
Details and how to check if you qualify · NCT05922878 on ClinicalTrials.gov
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Ages 18 Years to 75 Years · 43 sites · Draig Therapeutics Ltd
Details and how to check if you qualify · NCT07300969 on ClinicalTrials.gov
A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Ages 18 Years to no maximum · 57 sites · Neurocrine Biosciences
Details and how to check if you qualify · NCT07196501 on ClinicalTrials.gov
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
Ages 18 Years to 65 Years · 5 sites · Ludwig-Maximilians - University of Munich
iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder
Ages 14 Years to 45 Years · 1 site · Shanghai Mental Health Center
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder
Ages 7 Years to 17 Years · 0 sites · Bausch Health Americas, Inc.
Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU
Ages 15 Years to 18 Years · 1 site · Universidad de los Andes, Chile
Stony Brook Medicine Anti-Inflammatory Trial
Ages 18 Years to 65 Years · 0 sites · Stony Brook University
Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial
Ages 18 Years to 70 Years · 0 sites · Universitat Jaume I
A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms
Ages 18 Years to no maximum · 1 site · VA Office of Research and Development
Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.
Ages 18 Years to 18 Years · 0 sites · Sohag University
A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients
Ages 21 Years to 85 Years · 1 site · BioLite, Inc.
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications
Ages 18 Years to 60 Years · 1 site · Central South University
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
Ages 20 Years to 60 Years · 1 site · Universiti Sains Malaysia
Group PACBT for Depression
Ages 21 Years to 60 Years · 1 site · University of California, Los Angeles
Optimizing Stimulation Parameters for Electroconvulsive Therapy
Ages No minimum to no maximum · 1 site · University of Pennsylvania
Sham-Controlled Rapid-Acting Neuromodulation for Depression
Ages 18 Years to 65 Years · 1 site · University of California, Davis
Accelerated iTBS for Depression and Suicidality
Ages 18 Years to 90 Years · 0 sites · University of Iowa
Individual Narratives of Stimulation (ECT and TMS)
Ages 18 Years to no maximum · 2 sites · University of Nottingham
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
Ages 50 Years to no maximum · 1 site · Zealand University Hospital
Mobile Cognitive Behavioral Therapy in Early Stroke Recovery
Ages 18 Years to 79 Years · 1 site · Weill Medical College of Cornell University
Acupuncture and Escitalopram for Treating Major Depression Clinical Study
Ages 18 Years to 75 Years · 3 sites · Shanghai 7th People's Hospital
Slow-Paced Breathing and Electrical Vagus Nerve Stimulation as Add-on Treatments for Depression
Ages 18 Years to 60 Years · 1 site · Elisabeth Balint
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
Ages 18 Years to 65 Years · 27 sites · Bristol-Myers Squibb
Neural Correlates of Suicidal Behavior in Youth
Ages 14 Years to 24 Years · 1 site · The Cleveland Clinic
A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder
Ages 18 Years to 74 Years · 0 sites · Intra-Cellular Therapies, Inc.
Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of Clinical Efficacy and Neurobiological Mechanisms
Ages 18 Years to 55 Years · 1 site · Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
Ages 18 Years to 75 Years · 1 site · University of Kentucky
Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression
Ages 18 Years to 70 Years · 1 site · University of California, San Diego
Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
Ages 18 Years to 59 Years · 1 site · New York State Psychiatric Institute
Oral and Sublingual Ketamine
Ages 18 Years to 65 Years · 0 sites · Western University, Canada
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
Ages 60 Years to no maximum · 1 site · Washington University School of Medicine
Shortened LSD Intervention for Major Depressive Disorder
Ages 21 Years to 70 Years · 1 site · Johns Hopkins University
Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression
Ages 18 Years to 65 Years · 1 site · Namik Kemal University
Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder
Ages 18 Years to 60 Years · 0 sites · First People's Hospital of Hangzhou
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
Ages 12 Years to 18 Years · 1 site · First Affiliated Hospital of Chongqing Medical University
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Ages 12 Years to 16 Years · 2 sites · University of North Carolina, Chapel Hill
Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents
Ages 8 Years to 17 Years · 0 sites · Massachusetts General Hospital
Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial
Ages 22 Years to 80 Years · 0 sites · Brigham and Women's Hospital
Predictors of Treatment Outcome in Major Depressive Disorder
Ages 18 Years to 60 Years · 0 sites · Assiut University
PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood
Ages 18 Years to 65 Years · 1 site · University of Oxford
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
Ages 18 Years to 65 Years · 1 site · Sunnybrook Health Sciences Centre
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
Ages 21 Years to 55 Years · 2 sites · Sherwood Brown, MD, PhD
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
Ages 18 Years to 65 Years · 1 site · University Maribor
iPath for CP Pilot
Ages 18 Years to no maximum · 0 sites · Dartmouth-Hitchcock Medical Center
Prescribing the Right Agent for Depression in Adults (PRADA): a Double-blind, Randomised Controlled Trial Using a Web-based Multi-modal Clinical Decision Support System and Genetic Information to Personalise Antidepressant Treatment in Diverse Clinical Settings Across the Globe
Ages 18 Years to 74 Years · 3 sites · University of Oxford
tDCS for Late-Life Depression
Ages 60 Years to no maximum · 1 site · Andre Russowsky Brunoni
Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant Monotherapy
Ages 19 Years to 64 Years · 0 sites · Bukwang Pharmaceutical
Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive Disorder
Ages 18 Years to 55 Years · 0 sites · Central South University
Individualized fMRI-guided TMS for Depression
Ages 18 Years to 65 Years · 1 site · University of Pennsylvania
Fasting, Exercise, and Diet to Activate Autophagy in Depression
Ages 18 Years to 40 Years · 1 site · University of Zurich
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress
Ages 18 Years to no maximum · 1 site · Endeavor Health
An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.
Ages 18 Years to no maximum · 1 site · University of Pittsburgh
One-Day cTBS Over the Precuneus
Ages 18 Years to no maximum · 1 site · Mclean Hospital
AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico)
Ages 16 Years to 25 Years · 1 site · Accexible
The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and Depression Rate Among Survivors of Tidal Flooding in Sayung Demak
Ages 18 Years to 60 Years · 1 site · Natalia Dewi Wardani, MD
The Effect of Mindfulness in Inflammation Markers (IL-6, TNF-A, CRP and Cortisol) Among Survivors of Tidal Flooding in Sayung Demak
Ages 18 Years to 60 Years · 1 site · Natalia Dewi Wardani, MD
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
Ages 18 Years to no maximum · 1 site · Mclean Hospital
Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder
Ages 18 Years to no maximum · 1 site · Centre Psychothérapique de Nancy
PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder
Ages 18 Years to no maximum · 0 sites · Central Hospital, Nancy, France
Non-Coding RNAs Gene Expression in Psychiatric Disorders
Ages 18 Years to 55 Years · 5 sites · Carmen Concerto
Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Ages 18 Years to 55 Years · 2 sites · Gulhane Training and Research Hospital
Lumateperone for Late-Life Depression
Ages 60 Years to no maximum · 2 sites · Eric Lenze
Painhunting Therapy Versus Cognitive Behavioural Therapy for Event-Related Depression
Ages No minimum to no maximum · 1 site · Painhunting LLP
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Ages 18 Years to no maximum · 1 site · Mclean Hospital
Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning
Ages 18 Years to no maximum · 1 site · Dr. Nils B. Kroemer
Pregnenolone for Cannabis Use Disorder and Depression
Ages 18 Years to 50 Years · 2 sites · University of Texas Southwestern Medical Center
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder
Ages 22 Years to no maximum · 1 site · Pulvinar Neuro, LLC
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Ages 22 Years to 85 Years · 2 sites · Motif Neurotech, Inc.
REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness
Ages 22 Years to no maximum · 2 sites · Yale University
Student Precarity and Psychiatry
Ages 18 Years to no maximum · 0 sites · Assistance Publique - Hôpitaux de Paris
Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional Blunting
Ages 18 Years to 75 Years · 1 site · Future Options Research, LLC
Sedation and Guided Education for Depression Study
Ages 18 Years to no maximum · 0 sites · Stanford University
Context-Guided Personalized iTBS for Depression
Ages 18 Years to 55 Years · 1 site · Capital Medical University
Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)
Ages 13 Years to 17 Years · 1 site · Edward Via Virginia College of Osteopathic Medicine
Personalized Accelerated iTBS Versus Sham for Major Depressive Disorder
Ages 22 Years to 65 Years · 0 sites · Capital Medical University
Deaf CBT-TS to Reduce Suicide Risk
Ages 18 Years to no maximum · 1 site · University of Rochester
Early Detection of Perinatal Depression With Wearable Technology
Ages 16 Years to no maximum · 1 site · Women's College Hospital
Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients
Ages 18 Years to 80 Years · 1 site · Hospital Ambroise Paré Paris
Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression
Ages 18 Years to 65 Years · 1 site · The Royal's Institute of Mental Health Research
Precision Depression Adalimumab Trial
Ages 18 Years to no maximum · 1 site · Daniel Moriarity
Accelerated iTBS for PTSD and Depression
Ages 18 Years to no maximum · 1 site · Lawson Research Institute of St. Joseph's
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
Ages 18 Years to 69 Years · 0 sites · University of New Mexico
Sleep Disturbances and Their Association With Serum Magnesium Level in Patients With Major Depressive Disorder
Ages 18 Years to no maximum · 0 sites · Assiut University
The Medically Tailored Groceries and Mental Health Study
Ages 18 Years to no maximum · 3 sites · University of Massachusetts, Worcester
Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder
Ages 18 Years to 65 Years · 1 site · Military Hospital 175
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression
Ages 18 Years to 65 Years · 1 site · Shanghai Mental Health Center
Preoperative Anxiety and Depression Among Older Chinese Patients
Ages 65 Years to 100 Years · 0 sites · Chinese PLA General Hospital
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Ages 18 Years to no maximum · 0 sites · Massachusetts General Hospital
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
Ages 65 Years to 100 Years · 0 sites · Chinese PLA General Hospital
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Ages 18 Years to 75 Years · 169 sites · Eli Lilly and Company
Enhancing Veteran-Clinical Collaboration in VA PRRCs
Ages 18 Years to no maximum · 3 sites · VA Office of Research and Development
Biomarker-Guided Antidepressant Selection
Ages 18 Years to 70 Years · 1 site · Weill Medical College of Cornell University
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - Maintenance
Ages 22 Years to 85 Years · 0 sites · Motif Neurotech, Inc.
Psilocybin to Treat Depression in Spinal Cord Injury
Ages 22 Years to no maximum · 1 site · James J. Peters Veterans Affairs Medical Center
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
Ages 18 Years to 75 Years · 5 sites · VA Office of Research and Development
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
Ages 21 Years to 65 Years · 1 site · Ohio State University
Augmented Depression Therapy (ADepT) Case Series
Ages 18 Years to 65 Years · 1 site · Ohio State University
Inhaled DMT for Major Depressive Disorder
Ages 18 Years to no maximum · 5 sites · Universidade Federal do Rio Grande do Norte
Efficacy and Safety of Accelerated Intermittent Theta-burst Stimulation (a-iTBS) in Adolescents With Depressive Disorder
Ages 12 Years to 18 Years · 1 site · First Affiliated Hospital of Chongqing Medical University
More: Acne clinical trials · Alzheimer’s disease and related dementias clinical trials · Cannabis use disorder clinical trials · Chronic hives (chronic urticaria) clinical trials · COPD (chronic obstructive pulmonary disease) clinical trials · Moderately to severely active crohn's disease clinical trials
