Cannabis use disorder clinical trials

Mental health

By location or age: Colorado · Texas

110 trials are recruiting, according to ClinicalTrials.gov.

Showing 100 of 110, newest first. Checked against the registry on 5 October 2026. Listing a trial here is not a recommendation; taking part is voluntary and each study team decides who is eligible.

Recruiting · Phase 2 · Listed on Beacon

Longitudinal Outpatient Treatment for Cannabis Use Disorder

Ages 21 Years to no maximum · 1 site · University of Colorado, Boulder

Details and how to check if you qualify · NCT06107062 on ClinicalTrials.gov

Recruiting · Phase 3 · Listed on Beacon

Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder

Ages 18 Years to 55 Years · 22 sites · PleoPharma, Inc.

Details and how to check if you qualify · NCT07644052 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder

Ages 15 Years to 21 Years · 1 site · University of Minnesota

NCT07634835 on ClinicalTrials.gov

Not yet recruiting · Phase 2

Tirzepatide for the Treatment of Cannabis Use Disorder

Ages 18 Years to no maximum · 0 sites · Brigham and Women's Hospital

NCT07265752 on ClinicalTrials.gov

Not yet recruiting · Phase 2

FASD Prevention R33

Ages 18 Years to no maximum · 1 site · Philadelphia College of Osteopathic Medicine

NCT07828275 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Activity-Based Intervention to Address Cannabis Use

Ages 18 Years to 70 Years · 1 site · University of Michigan

NCT07813442 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Applying Mixed Methods to Identify Links Between PTSD Symptoms, Cannabis Use, and Functional Behaviors With Personalized Feedback Intervention Development

Ages 18 Years to 75 Years · 1 site · VA Office of Research and Development

NCT07721285 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Clinician Practice Companion to Address Youth Substance Use

Ages 14 Years to 24 Years · 5 sites · Massachusetts General Hospital

NCT07725289 on ClinicalTrials.gov

Not yet recruiting · Phase 2

Varenicline as a Treatment for Cannabis Use Disorder

Ages 18 Years to no maximum · 0 sites · Medical University of South Carolina

NCT07783555 on ClinicalTrials.gov

Not yet recruiting · Phase 2

Trial of Tirzepatide for the Treatment of Cannabis Use Disorder

Ages 18 Years to 70 Years · 0 sites · National Institute on Drug Abuse (NIDA)

NCT07468552 on ClinicalTrials.gov

Not yet recruiting · Phase 4

Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder

Ages 16 Years to 26 Years · 1 site · Massachusetts General Hospital

NCT07838311 on ClinicalTrials.gov

Not yet recruiting · Phase 1 / Phase 2

Lemborexant for Cannabis Use Disorder

Ages 18 Years to 65 Years · 1 site · University of Calgary

NCT07802990 on ClinicalTrials.gov

Not yet recruiting · Phase 1

Cannabis and Opioid Use Disorder, Study 2

Ages 18 Years to 55 Years · 1 site · University of Kentucky

NCT07661446 on ClinicalTrials.gov

Not yet recruiting · Early Phase 1

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

Ages 18 Years to 55 Years · 1 site · Hannah Harris

NCT07694466 on ClinicalTrials.gov

Not yet recruiting · Phase 1

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

Ages 18 Years to 60 Years · 1 site · Johns Hopkins University

NCT06351540 on ClinicalTrials.gov

Not yet recruiting · Phase 1

Cannabis Effects on Opioid Self-Administration

Ages 18 Years to 55 Years · 1 site · Shanna Babalonis, PhD

NCT07668635 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis

Ages 18 Years to 35 Years · 0 sites · Centre hospitalier de l'Université de Montréal (CHUM)

NCT07811466 on ClinicalTrials.gov

Not yet recruiting · Phase 2

Endocannabinoids in Reward

Ages 21 Years to 45 Years · 1 site · Medical University of South Carolina

NCT07815691 on ClinicalTrials.gov

Recruiting · Phase 1

Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes

Ages 21 Years to 55 Years · 1 site · Johns Hopkins University

NCT07214155 on ClinicalTrials.gov

Recruiting · Phase 2

Acute Effects of Cannabis on Cognition and Affect

Ages 21 Years to no maximum · 1 site · Washington State University

NCT07296874 on ClinicalTrials.gov

Not yet recruiting · Not applicable

LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School

Ages 15 Years to 21 Years · 0 sites · Prevention Strategies, LLC

NCT07655609 on ClinicalTrials.gov

Not yet recruiting · Not applicable

QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360)

Ages 17 Years to 99 Years · 1 site · Veterans Recovery Network Inc.

NCT07661823 on ClinicalTrials.gov

Not yet recruiting · Phase 1 / Phase 2

Pregnenolone for Cannabis Use Disorder and Depression

Ages 18 Years to 50 Years · 2 sites · University of Texas Southwestern Medical Center

NCT07685964 on ClinicalTrials.gov

Not yet recruiting · Phase 1 / Phase 2

Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery

Ages 18 Years to 60 Years · 1 site · Leslie Lundahl

NCT06222268 on ClinicalTrials.gov

Not yet recruiting · Phase 3

Tirzepatide in the Treatment of Cannabis Use Disorder

Ages 18 Years to no maximum · 1 site · McMaster University

NCT07671248 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing

Ages 21 Years to 65 Years · 1 site · The Mind Research Network

NCT07787572 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

Ages 18 Years to no maximum · 1 site · Loma Linda University

NCT07001371 on ClinicalTrials.gov

Not yet recruiting · Early Phase 1

Research Investigating Drug Effects-2 (RiDE-2)

Ages 18 Years to 21 Years · 1 site · University of Illinois at Chicago

NCT06758596 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Developing and Strengthening Cannabis Warnings: Warning Message Testing

Ages 18 Years to no maximum · 1 site · University of North Carolina, Chapel Hill

NCT07699198 on ClinicalTrials.gov

Recruiting · Not applicable

Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

Ages 18 Years to no maximum · 1 site · University of Pittsburgh

NCT07489443 on ClinicalTrials.gov

Recruiting · Not applicable

Neuroimaging of Adolescent Cannabis Use Treatment

Ages 14 Years to 17 Years · 1 site · Indiana University

NCT07340554 on ClinicalTrials.gov

Recruiting · Phase 2

Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder

Ages 18 Years to 70 Years · 1 site · Anders Fink-Jensen, MD, DMSci

NCT07523633 on ClinicalTrials.gov

Recruiting · Not applicable

Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis

Ages 16 Years to 30 Years · 2 sites · Nova Scotia Health Authority

NCT07056894 on ClinicalTrials.gov

Recruiting · Not applicable

Psychiatric Symptom Characteristics in Methamphetamine-Induced Psychosis With and Without Lifetime Cannabis Use

Ages 18 Years to 65 Years · 2 sites · Elazığ Mental Health and Diseases Hospital

NCT07459270 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis Reduction and Functional Outcomes

Ages 18 Years to no maximum · 1 site · Medical University of South Carolina

NCT07218471 on ClinicalTrials.gov

Recruiting · Not applicable

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Ages 18 Years to no maximum · 1 site · Massachusetts General Hospital

NCT06878859 on ClinicalTrials.gov

Not yet recruiting · Not applicable

A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients

Ages 16 Years to no maximum · 1 site · St. Joseph's Healthcare Hamilton

NCT07387965 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis and Processing Emotions Study

Ages 18 Years to 50 Years · 1 site · Auburn University

NCT06907979 on ClinicalTrials.gov

Recruiting · Not applicable

A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

Ages 18 Years to no maximum · 11 sites · City of Hope Medical Center

NCT07225738 on ClinicalTrials.gov

Recruiting · Not applicable

Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia

Ages 18 Years to 65 Years · 1 site · Vanderbilt University Medical Center

NCT07196462 on ClinicalTrials.gov

Recruiting · Not applicable

Impact of Cannabis Use During Third Molar Surgery

Ages 16 Years to 99 Years · 1 site · University of Michigan

NCT07423195 on ClinicalTrials.gov

Enrolling by invitation · Not applicable

Investigating Cannabis Use Parameters on Anesthesia and Inflammation in Lumbar Spinal Surgeries

Ages 18 Years to no maximum · 2 sites · University of Missouri-Columbia

NCT07354412 on ClinicalTrials.gov

Recruiting · Not applicable

Virtual Reality (VR-GINSO) as an Complement to Intervention for Alcohol and Cannabis Use in Youth in Residential Care

Ages 13 Years to 21 Years · 1 site · Universidad Francisco de Vitoria

NCT07834606 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)

Ages 18 Years to 65 Years · 1 site · King's College London

NCT07245212 on ClinicalTrials.gov

Not yet recruiting · Early Phase 1

THC + CBD and Memory Study

Ages 18 Years to 40 Years · 0 sites · Hartford Hospital

NCT04855526 on ClinicalTrials.gov

Recruiting · Not applicable

RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative

Ages 22 Years to 65 Years · 1 site · NYU Langone Health

NCT07184983 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Skills for Talking About Cannabis for Families of Young Adults With Psychosis

Ages 18 Years to no maximum · 1 site · University of Washington

NCT06961877 on ClinicalTrials.gov

Recruiting · Not applicable

Study of an Oral Fluid Testing Approach

Ages 18 Years to 30 Years · 1 site · Boston Children's Hospital

NCT06891235 on ClinicalTrials.gov

Recruiting · Phase 1 / Phase 2

Warrior CARE: Cannabis Behavioral Health

Ages 19 Years to 69 Years · 1 site · Wayne State University

NCT06381180 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)

Ages 18 Years to no maximum · 1 site · HealthPartners Institute

NCT07227324 on ClinicalTrials.gov

Recruiting · Not applicable

Exercise Intervention as Treatment for People Using Cannabis (ExIT-C)

Ages 18 Years to 40 Years · 1 site · The University of Hong Kong

NCT07091292 on ClinicalTrials.gov

Recruiting · Not applicable

Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

Ages 18 Years to 29 Years · 1 site · University of Washington

NCT06736444 on ClinicalTrials.gov

Recruiting · Phase 2

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Ages 21 Years to 65 Years · 1 site · University of California, San Francisco

NCT05999383 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Cannabis Association With Sleep Study

Ages 21 Years to 29 Years · 0 sites · Oregon Health and Science University

NCT06982950 on ClinicalTrials.gov

Recruiting · Not applicable

Medical Cannabis and Behavior

Ages 30 Years to 75 Years · 1 site · University of Minnesota

NCT06808048 on ClinicalTrials.gov

Recruiting · Phase 3

Cannabis-Tobacco Co-Use Treatment Study

Ages 18 Years to no maximum · 1 site · Medical University of South Carolina

NCT06883162 on ClinicalTrials.gov

Recruiting · Phase 1

Effect of Cannabis on E-Cigarette Use Behavior

Ages 21 Years to no maximum · 1 site · Johns Hopkins University

NCT06609109 on ClinicalTrials.gov

Recruiting · Phase 4

Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis

Ages 18 Years to 25 Years · 2 sites · Nova Scotia Health Authority

NCT07001878 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults

Ages 18 Years to 25 Years · 1 site · University of Pittsburgh

NCT06743373 on ClinicalTrials.gov

Recruiting · Phase 4

E-cigarette Cessation in Adults Who Co-use Cannabis

Ages 18 Years to 40 Years · 3 sites · Medical University of South Carolina

NCT06688539 on ClinicalTrials.gov

Recruiting · Not applicable

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Ages 18 Years to no maximum · 467 sites · Wake Forest University Health Sciences

NCT06418204 on ClinicalTrials.gov

Recruiting · Phase 1

Effect of Cannabis on Cigarette Use Behavior

Ages 21 Years to no maximum · 1 site · Johns Hopkins University

NCT06609083 on ClinicalTrials.gov

Recruiting · Not applicable

Stress and Pain in People Living With HIV

Ages 18 Years to 68 Years · 1 site · Yale University

NCT06784908 on ClinicalTrials.gov

Recruiting · Phase 1

HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)

Ages 50 Years to no maximum · 1 site · Yale University

NCT06513819 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Substance Use Screening to Encourage Behavior Change Among Young People in Primary Care

Ages 14 Years to 24 Years · 1 site · Prof. Dagmar M. Haller

NCT04146714 on ClinicalTrials.gov

Recruiting · Not applicable

A Mobile App to Reduce and/or Quit Cannabis Use

Ages 18 Years to 30 Years · 1 site · Alba González-Roz, PhD

NCT06733792 on ClinicalTrials.gov

Enrolling by invitation · Not applicable

Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults

Ages 18 Years to 26 Years · 1 site · Boston Children's Hospital

NCT06661031 on ClinicalTrials.gov

Recruiting · Phase 2

A Study of Cannabidiol in Young Adult Cannabis Users

Ages 18 Years to 25 Years · 1 site · University of Colorado, Denver

NCT06569394 on ClinicalTrials.gov

Recruiting · Phase 2

Cannabidiol and Cannabis Concentrate Users

Ages 25 Years to 60 Years · 1 site · University of Colorado, Denver

NCT06575751 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis Abstinence and Neurocognitive Assessment in Adolescence

Ages 15 Years to 18 Years · 1 site · University Hospital Pilsen

NCT07160153 on ClinicalTrials.gov

Recruiting · Not applicable

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

Ages 14 Years to 21 Years · 2 sites · Massachusetts General Hospital

NCT06395467 on ClinicalTrials.gov

Recruiting · Phase 1

Psilocybin-assisted Treatment for Cannabis Use Disorder

Ages 18 Years to no maximum · 1 site · Johns Hopkins University

NCT06660381 on ClinicalTrials.gov

Recruiting · Not applicable

A Brief Intervention for Cannabis Use

Ages 18 Years to 25 Years · 1 site · Medical University of South Carolina

NCT06395389 on ClinicalTrials.gov

Recruiting · Phase 1

Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans

Ages 21 Years to 60 Years · 1 site · Yale University

NCT06058702 on ClinicalTrials.gov

Recruiting · Phase 1

Cannabis and Opioid Use Disorder

Ages 18 Years to 55 Years · 1 site · Shanna Babalonis, PhD

NCT05729932 on ClinicalTrials.gov

Not yet recruiting · Not applicable

MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education

Ages 18 Years to no maximum · 0 sites · California State University, Northridge

NCT06553196 on ClinicalTrials.gov

Recruiting · Not applicable

Role of Pavlovian Mechanisms for Control Over Substance Use

Ages 18 Years to 65 Years · 1 site · Technische Universität Dresden

NCT06701487 on ClinicalTrials.gov

Recruiting · Phase 2

Effects of THC on Alcohol Consumption and Neural Correlates of Reward

Ages 21 Years to 40 Years · 1 site · University of Colorado, Denver

NCT06446479 on ClinicalTrials.gov

Recruiting · Phase 2

Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy

Ages 25 Years to no maximum · 1 site · BC Centre on Substance Use

NCT05985850 on ClinicalTrials.gov

Recruiting · Not applicable

Young Adult Tobacco/Nicotine and Cannabis Co-use

Ages 18 Years to 25 Years · 1 site · Medical University of South Carolina

NCT06239350 on ClinicalTrials.gov

Enrolling by invitation · Not applicable

Alcohol and Cannabis Use Among Pregnant Slovenian Women

Ages No minimum to no maximum · 1 site · University Medical Centre Ljubljana

NCT07456579 on ClinicalTrials.gov

Recruiting · Not applicable

Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

Ages 15 Years to 18 Years · 1 site · University of Minnesota

NCT06124846 on ClinicalTrials.gov

Recruiting · Not applicable

Age Differences in the Effects of Cannabis on Simulated Driving

Ages 19 Years to 45 Years · 1 site · Centre for Addiction and Mental Health

NCT04325958 on ClinicalTrials.gov

Recruiting · Phase 1 / Phase 2

Mitigating PTSD-CUD After Sexual Assault

Ages 18 Years to no maximum · 6 sites · University of Nevada, Las Vegas

NCT05989841 on ClinicalTrials.gov

Not yet recruiting · Not applicable

Impact of tDCS on Cannabis Craving in Schizophrenia

Ages 18 Years to 65 Years · 2 sites · Centre hospitalier de Ville-Evrard, France

NCT05784961 on ClinicalTrials.gov

Recruiting · Not applicable

Rewards for Cannabis Abstinence-study

Ages 16 Years to 22 Years · 5 sites · Parnassia Addiction Research Centre

NCT05836207 on ClinicalTrials.gov

Recruiting · Not applicable

Real World Evidence on the Use of Medical Cannabis in Pediatrics

Ages 3 Years to 17 Years · 1 site · University of Manitoba

NCT05863910 on ClinicalTrials.gov

Recruiting · Phase 1 / Phase 2

SCORE Emerging Adult Cannabis Use & Stress

Ages 18 Years to 25 Years · 1 site · Medical University of South Carolina

NCT05885542 on ClinicalTrials.gov

Recruiting · Phase 2

Guanfacine Extended-release for Adolescents With Cannabis Use

Ages 12 Years to 25 Years · 1 site · Orygen

NCT05957848 on ClinicalTrials.gov

Recruiting · Not applicable

Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use

Ages 21 Years to no maximum · 1 site · University of Michigan

NCT05814822 on ClinicalTrials.gov

Recruiting · Not applicable

Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder

Ages 18 Years to 65 Years · 1 site · Centre for Addiction and Mental Health

NCT05859347 on ClinicalTrials.gov

Recruiting · Early Phase 1

Cannabis Use, Cognition, and the Endocannabinoid System in HIV

Ages 18 Years to 65 Years · 1 site · University of California, San Diego

NCT04883255 on ClinicalTrials.gov

Recruiting · Phase 2 / Phase 3

Alcohol Use Disorder and Cannabidiol

Ages 21 Years to no maximum · 1 site · University of Colorado, Denver

NCT05613608 on ClinicalTrials.gov

Recruiting · Not applicable

Cannabis Use and Outcomes in Black and White Patients With Cancer

Ages 21 Years to 99 Years · 3 sites · State University of New York at Buffalo

NCT06037681 on ClinicalTrials.gov

Recruiting · Phase 2

Cannabis' Impact on Alcohol Consumption

Ages 21 Years to 50 Years · 1 site · Brown University

NCT05389930 on ClinicalTrials.gov

Recruiting · Not applicable

Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia

Ages 18 Years to 60 Years · 8 sites · Centre Hospitalier Universitaire de Saint Etienne

NCT04871048 on ClinicalTrials.gov

Recruiting · Not applicable

RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic Disorders

Ages 18 Years to no maximum · 1 site · Ciusss de L'Est de l'Île de Montréal

NCT05704582 on ClinicalTrials.gov

Recruiting · Not applicable

CARS: Cannabis and Alcohol Reduction Study

Ages 13 Years to 17 Years · 1 site · Medical University of South Carolina

NCT05486234 on ClinicalTrials.gov

Recruiting · Not applicable

Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment

Ages 18 Years to no maximum · 1 site · Centre for Addiction and Mental Health

NCT05855668 on ClinicalTrials.gov

Recruiting · Not applicable

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

Ages 18 Years to 65 Years · 1 site · Duke University

NCT05401929 on ClinicalTrials.gov

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