COPD (chronic obstructive pulmonary disease) clinical trials
Medical name: Chronic obstructive pulmonary disease · Lungs & breathing
664 trials are recruiting, according to ClinicalTrials.gov.
Showing 100 of 664, newest first. Checked against the registry on 5 October 2026. Listing a trial here is not a recommendation; taking part is voluntary and each study team decides who is eligible.
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Ages 40 Years to 80 Years · 243 sites · AstraZeneca
Details and how to check if you qualify · NCT06878261 on ClinicalTrials.gov
Developing an Intervention to Optimize Virtual Care Adoption for COPD Management
Ages 40 Years to no maximum · 2 sites · VA Office of Research and Development
Remote Intervention Versus Routine Monitoring in COPD Patients With Chronic Hypercapnia Receiving Home Non-invasive Respiratory Support
Ages 40 Years to 80 Years · 4 sites · Sir Run Run Shaw Hospital
RSV Vaccination to Reduce Recurrent AECOPD
Ages 50 Years to no maximum · 1 site · Chinese University of Hong Kong
cfMSC Stem Cell Therapy Targeting COPD
Ages 40 Years to 80 Years · 1 site · Shenzhen Geno-Immune Medical Institute
Comparative Effectiveness of Roflumilast and Azithromycin in Reducing Exacerbations in Severe Chronic Obstructive Pulmonary Disease ( COPD ) Patients With Chronic Bronchitis Phenotype
Ages 40 Years to no maximum · 0 sites · Sidra Aziz
Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR)
Ages 40 Years to no maximum · 1 site · Eurofarma Laboratorios S.A.
Pulmonary Rehabilitation Frequency in COPD Patients
Ages No minimum to no maximum · 0 sites · Hospital Universitario Fundación Alcorcón
A Study of the Effect of a Nurse Navigator Program on High Risk Patients
Ages 18 Years to no maximum · 1 site · Mayo Clinic
Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD
Ages 40 Years to no maximum · 1 site · University of Milan
Effect of add-on Doxofylline on Lung Function in Stable COPD
Ages 40 Years to no maximum · 1 site · University of Milan
Portable Positive Pressure Therapy Device
Ages 21 Years to 85 Years · 0 sites · Koronis Biomedical Technologies
The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD
Ages 18 Years to 85 Years · 0 sites · University of Alberta
Home-based Pulmonary Rehabilitation for COPD Patients
Ages 40 Years to 100 Years · 1 site · Karolinska Institutet
Validation of 1 Minute Sit-to Stand Test for Assessment of Breathlessness at Exertion in Individuals With Chronic Lung Disease
Ages 18 Years to no maximum · 1 site · Jacob Sandberg
Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD
Ages 45 Years to no maximum · 1 site · University Hospital, Grenoble
A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
Ages 18 Years to 80 Years · 0 sites · Hoffmann-La Roche
COINCIDE: CardineurOvascular dIsease aNd obstruCtive aIrway DiseasE
Ages 18 Years to no maximum · 0 sites · VASCage GmbH
Indoor Overheating and Physiological Strain in Older Adults With COPD
Ages 60 Years to 80 Years · 1 site · University of Ottawa
Investigation of the Effect of Structured Energy Conservation Techniques Training on COPD Patients
Ages 40 Years to no maximum · 1 site · Akdeniz University
The Impact of Indoor Environmental Quality on Symptoms in Patients With Chronic Obstructive Pulmonary Disease
Ages 18 Years to no maximum · 1 site · Ziekenhuis Oost-Limburg
Feasibility of Noninvasive Trigeminal Nerve Stimulation During Exercise
Ages 18 Years to 75 Years · 0 sites · Johns Hopkins University
Improving Medication Management in COPD
Ages 45 Years to no maximum · 0 sites · Duke University
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
Ages 55 Years to 85 Years · 0 sites · Western University, Canada
Primary Palliative Care - a Feasibility Cluster Trial
Ages 18 Years to no maximum · 2 sites · University of Coimbra
THERMotherapy Against Persistent Bacterial LUNG Infections
Ages 18 Years to no maximum · 1 site · Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Ages 60 Years to no maximum · 0 sites · Assiut University
A Clinical Study of REGEND001 for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Ages 40 Years to 75 Years · 1 site · Regend Therapeutics
Comparison of Arterial and Capillary Blood Gas Analyses in Patients With Respiratory Distress Due to COPD or APE
Ages 18 Years to no maximum · 1 site · Centre Hospitalier Universitaire de Nice
The CANadian EXAcerbation of COPD Trial
Ages 40 Years to no maximum · 1 site · McGill University Health Centre/Research Institute of the McGill University Health Centre
A Continuation Study of Tilrekimig in Adults With Moderate-to-Severe Long-Term Breathing Difficulty, Known by the Medical Term of Chronic Obstructive Pulmonary Disease (COPD) to Learn About This Medicine When Used for a Long Period of Time
Ages 35 Years to 80 Years · 0 sites · Pfizer
BREZTRI REGULATORY POST MARKETING SURVEILLANCE IN KOREA
Ages No minimum to no maximum · 10 sites · AstraZeneca
A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)
Ages 40 Years to 80 Years · 3 sites · Sanofi
RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD
Ages 40 Years to no maximum · 0 sites · Medical University of South Carolina
A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-2)
Ages 40 Years to 80 Years · 4 sites · GlaxoSmithKline
Titrated Ambulatory Oxygen in Fibrotic ILD and COPD With Isolated Exertional Hypoxemia
Ages 18 Years to 85 Years · 1 site · State University of New York at Buffalo
New Diagnostic Approaches in the Management of Inflammatory Lung Diseases
Ages 18 Years to no maximum · 0 sites · Fondazione Don Carlo Gnocchi ETS
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Ages 40 Years to no maximum · 1 site · Assiut University
Cross-Regional Unmanned Aircraft Transport of Donor Lungs
Ages 18 Years to no maximum · 1 site · The First Affiliated Hospital of Guangzhou Medical University
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
Ages 65 Years to no maximum · 1 site · Duke University
Combinaison of Virtual Reality and Rehabilitation to Improve Muscle Function, Exercise Tolerance, Exertional Symptoms and Dyspnea in Patients With Chronic Respiratory Disease: a Randomized Cross-over Trial
Ages 18 Years to no maximum · 1 site · Fondation Hôpital Saint-Joseph
Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Ages 18 Years to 85 Years · 1 site · ADIR Association
Immuno-inflammatory Response of Erdosteine in COPD
Ages 45 Years to no maximum · 1 site · Pierachille Santus, MD, PhD
FITME Study: Formulating Individualised Exercise Prescription in Chronic Obstructive Pulmonary Disease
Ages 18 Years to no maximum · 1 site · Aveiro University
Effects of Structural Integration on Chest Wall Expansion Among COPD Patients
Ages 50 Years to 70 Years · 1 site · Green International University
Pulmonary Rehabilitation in African Countries
Ages 18 Years to no maximum · 3 sites · University of Edinburgh
Effectiveness of Active Cycle of Breathing Techniques in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
Ages 40 Years to 90 Years · 1 site · National Yang Ming Chiao Tung University Hospital
HFNC During Bronchoscopy in COPD Patients
Ages 18 Years to no maximum · 0 sites · The First Affiliated Hospital of Guangzhou Medical University
ECHO-COPD: Impact of a Pharmacist-Led Health Belief Model-Based Educational Intervention Among Chronic Obstructive Pulmonary Disease Patients
Ages 18 Years to 65 Years · 1 site · Rabia Hussain
Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE
Ages 1 Year to 80 Years · 1 site · University Hospital, Bordeaux
Evaluation of the Benefits of Hypnosis in Improving the Quality of Life of Patients With Chronic Obstructive Pulmonary Disease (COPD) Suffering From Persistent Dyspnea
Ages 18 Years to no maximum · 1 site · Assistance Publique - Hôpitaux de Paris
A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD
Ages 40 Years to 82 Years · 0 sites · Rise Therapeutics LLC
Factors Associated With Acceptance of Home-Based Pulmonary Telerehabilitation in COPD
Ages 18 Years to no maximum · 1 site · ADIR Association
Phase 1 PK Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
Ages 18 Years to 55 Years · 1 site · AeroRx Therapeutics Inc.
Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings
Ages 18 Years to no maximum · 2 sites · University Hospital Southampton NHS Foundation Trust
Impact of Combined Cardio-pulmonary Assessment on COPD Clinical Management.
Ages 41 Years to no maximum · 0 sites · University of Bari Aldo Moro
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
Ages 18 Years to no maximum · 1 site · Hospital del Mar Research Institute (IMIM)
Modulating Locomotor-Respiratory Coupling Through Adaptive Exoskeleton Assistance in Patients With COPD
Ages 45 Years to 75 Years · 1 site · University of Nebraska
EFFECTIVENESS OF COMBINED CONCENTRIC AND ECCENTRIC AEROBIC EXERCISE ON A TREADMILL IN PATIENTS WITH COPD: A RANDOMIZED CLINICAL TRIAL.
Ages 18 Years to no maximum · 1 site · Universidad Europea de Madrid
Muscle Oxygenation in Patients With COPD Exacerbation
Ages 40 Years to no maximum · 1 site · Hacettepe University
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease
Ages 18 Years to no maximum · 1 site · Zhejiang University
GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD
Ages 40 Years to 80 Years · 1 site · The Cleveland Clinic
The Effect of Pranayama Practiced With Rain Sounds on Self-Efficacy, Dyspnea, and Respiratory Functions in Patients With COPD
Ages 18 Years to no maximum · 0 sites · Inonu University
The Feasibility of Electrical Impedance Tomography to Guide Non-invasive Respiratory Interventions in Chronic Respiratory Disease
Ages 18 Years to no maximum · 1 site · Royal Free Hospital NHS Foundation Trust
A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-1)
Ages 40 Years to 80 Years · 2 sites · GlaxoSmithKline
Cognitive Load and Inhaler Technique in COPD
Ages 18 Years to 100 Years · 1 site · Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Rademikibart IV for Acute Asthma and COPD Exacerbation
Ages 18 Years to 85 Years · 2 sites · Connect Biopharm LLC
TCM Cohort for Elderly COPD
Ages 60 Years to no maximum · 1 site · Henan University of Traditional Chinese Medicine
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Ages 18 Years to no maximum · 6 sites · Ohio State University
Induced Sputum Collection in COPD Patients With and Without a Vibroacoustic Device
Ages 40 Years to 70 Years · 1 site · Fraunhofer-Institute of Toxicology and Experimental Medicine
A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Ages 40 Years to 75 Years · 127 sites · Eli Lilly and Company
The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry
Ages 40 Years to no maximum · 3 sites · Sanofi
Effect of Exercise Order During Pulmonary Rehabilitation on Muscle Strength in Patients With COPD
Ages 18 Years to no maximum · 1 site · CHU de Reims
Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD
Ages 18 Years to no maximum · 7 sites · VA Office of Research and Development
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of KIT2014 in Patients With Moderate to Severe COPD
Ages 40 Years to 80 Years · 2 sites · Kither Biotech Srl
Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study
Ages 30 Years to 85 Years · 1 site · Nanfang Hospital, Southern Medical University
PRA-216 COPD Safety and Biomarker Study
Ages 40 Years to 80 Years · 0 sites · Prana Therapies Inc
RESET-COPD Cohort: Real-Time Monitoring and Early Warning in COPD Patients Receiving Home NPPV
Ages 18 Years to no maximum · 0 sites · Beijing Chao Yang Hospital
Effectiveness of Xuanfei Jiangzhuo Decoction for Influenza-Induced AECOPD
Ages 60 Years to no maximum · 1 site · Tianjin Medical University
Effectiveness of the Telemonitoring Program for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Ages 18 Years to no maximum · 0 sites · Hope Care, S.A
Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD
Ages 18 Years to 90 Years · 1 site · Capital Development Authority (CDA)
Outpatient Rehabilitation Programmes for Myocardial Ischemia, Heart Failure, and COPD: Satisfaction, Participation, Test Outcomes, and Factors Associated With Positive Changes in Test Results as Well as Level of Participation
Ages 18 Years to no maximum · 0 sites · Nordsjaellands Hospital
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
Ages 19 Years to 100 Years · 1 site · Samsung Medical Center
Prevalence and Clinical Outcome of Eosinophilic COPD
Ages 40 Years to no maximum · 0 sites · Assiut University
Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD
Ages 18 Years to no maximum · 0 sites · Assiut University
DIVision of the Interlobar Fissure in Patients Who Do Not Respond to Endobronchial Lung Volume Reduction
Ages 18 Years to 75 Years · 0 sites · Rocco Bilancia
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases
Ages 3 Years to no maximum · 0 sites · The First Affiliated Hospital of Guangzhou Medical University
T2AIR: Real-World Efficacy and Safety of Biologics Targeting Type 2 Inflammation in Asthma and COPD
Ages 18 Years to no maximum · 1 site · Shanghai Pulmonary Hospital, Shanghai, China
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
Ages 40 Years to 80 Years · 9 sites · UCB Biopharma SRL
COPD-PTB Screening Trial in Henan, China
Ages 18 Years to no maximum · 0 sites · Henan Provincial People's Hospital
A Clinical Trial to Evaluate the Efficacy and Safety of HRS-9821 Inhalation Suspension in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
Ages 40 Years to 80 Years · 1 site · Guangdong Hengrui Pharmaceutical Co., Ltd
Interoception and Symptom Perception in Acute COPD Exacerbation
Ages 40 Years to 75 Years · 1 site · Saglik Bilimleri Universitesi
PEP Buddy in Pulmonary Rehabilitation
Ages 40 Years to 89 Years · 2 sites · VA Office of Research and Development
Effects of Adapted Snacktivity™ Intervention on Cognition and Self-Care in COPD Patients
Ages 60 Years to no maximum · 0 sites · The University of Hong Kong
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Ages 60 Years to no maximum · 2 sites · COPD Foundation
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of HSK39004 Inhalation Suspension in Patients With COPD
Ages 40 Years to 80 Years · 1 site · Haisco Pharmaceutical Group Co., Ltd.
Long-Term Safety and Efficacy of HSK39004 Inhalation Suspension in COPD
Ages 40 Years to 80 Years · 1 site · Haisco Pharmaceutical Group Co., Ltd.
A Phase I Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HRS-9821 Powder for Inhalation Administered as a Single Dose in Healthy Participants and Multiple Doses in Patients With COPD
Ages 18 Years to 75 Years · 1 site · Guangdong Hengrui Pharmaceutical Co., Ltd
MoblO2 to Maintain Oxygenation
Ages 25 Years to 95 Years · 1 site · Minnesota HealthSolutions
COPD Flare-Up Clinic After Severe Exacerbations
Ages 40 Years to 80 Years · 1 site · Tel-Aviv Sourasky Medical Center
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